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KMID : 0911820140150020062
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Korean Journal of Headache
2014 Volume.15 No. 2 p.62 ~ p.66
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Metabolic Syndrome in Patients with Migraine and Primary Headache Disorders: A Headache Clinic-Based Study
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Kim Byung-Su
Roh Sook-Young
Yu Hyun-Jeung
Jeong Eun-Hye
Sunwoo Mun-Kyung
Jang Hyun-Soon
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Abstract
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Background: Previous evidence has shown that migraine patients were at increased risk of cardiovascular disease. Unfavorable cardiovascular profile of migraineurs was one possible explanation for this relationship. In this study, we sought to investigate the proportions of metabolic syndrome (MetS) in primary headache and an association between
migraine and MetS.
Methods: We analyzed data of primary headache patients aged 19-69 years who first visited our headache clinic from April to August 2014. Using multivariate testing, odds ratio (OR) and 95% confidence interval (CI) were calculated to determine an association between migraine (reference: nonmigraine headache) and MetS.
Results: During the study period, 202 consecutive patients were enrolled in this study: 142 migraineurs, 24 tension-type headache (TTH) patients, 4 trigeminal autonomic cephalalgia (TAC) patients, and 32 patients with other primary headache disorders. The proportions of MetS among study patients were as follows: 26.1% for migraineurs, 41.7% for TTH patients, 50.0% for TAC patients, and 40.6% for patients with other primary headache disorders. In multivariate testing, age was associated with MetS (OR: 1.08, 95% CI: 1.05-1.12), whereas female was inversely related to MetS (OR: 0.43, 95% CI: 0.16-0.68). An adjusted odds ratio (95% confidence interval) for MetS comparing migraine to the reference (nonmigraine headache) was 0.88 (0.43-1.81).
Conclusion: In this study, the proportion of MetS was lower in migraineurs than in patients with non-migraine headache, because migraineurs tended to be younger and female. Our results suggest that migraine is not independently associated
with the risk of MetS, when compared to nonmigraine headache.
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KEYWORD
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Headache, Migraine, Metabolic syndrome, Obesity
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